Endocrine Abstracts

Introduction: Diabetes insipidus (DI) is a rare pathology. The advent of hypothalamic-pituitary MRI has made it possible to make a positive diagnosis by avoiding the water restriction test (WRT). The etiological diagnosis is still a challenge in view of the diversity of diseases involved, which influences the therapeutic management and prognosis.Work Objectives: The objectives of our work were to describe the clinical, paraclinical and genetic features o...

Introduction: Pituitary stalk thickening (PST) is often identified on magnetic resonance imaging (MRI), either incidentally or during diagnostic workup of hypopituitarism. Currently, there is no unified standard for the definition of PST. As a reference, a pituitary stalk with width over 3 mm has been used as the diagnostic criterion for PST in recent years. The disease spectrum of PST is quite diverse and can be grouped into three broad categories: neoplastic, inflammatory an...

Introduction: Growth hormone (GH) treatment in congenital growth hormone deficiency (CGHD) is indicated to improve the prognosis of the statural prognosis. The aim of this study is to identify the predictive factors of a favorable response to GH therapy.Patients & Methods: This is a retrospective study, conducted over a period of 27 years, including 30 patients with CGHD treated with hormonal therapy.Results: The CGHD was diagn...

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in pediatric patients, up to 95% in some studies.Observation: We report the observation of a 6-year-old female who consulted for a behavioral disorder made of agitation and lack of concentration. She had a family history of autoimmune thyroid disease. On examination, an accelerated statural growth rate of +2DS was noted. She had a significant palpebral retraction without ...

Amiodarone is considered by many the most potent antiarrhythmic drug. The other side of the coin is that it’s associated with many side effects including disturbances in the thyroid function, which can be seen in 14 to 18 % of the cases (1). This case is about a 56-year-old male patient with a history of mitral valve disease who was on Amiodarone for 3 years. His personal history was notable with Epilepsy of unknow etiology for which he was on sodium valproate. During fol...

Pituitary apoplexy is a rare condition and gestational pituitary apoplexy (GPA) is even more exceptional. Clinical presentation of GPA is often non-specific overlapping with other conditions, making its diagnosis challenging. Additionally, therapeutic management is often limited since it depends on both the mother’s and the fetus’s prognosis. Herein we report of a woman who was diagnosed with GPA and we discuss the management of her case. A 34-year-old woman with no ...

Background and aim: Congenital Growth hormone deficiency (CGHD) may result from genetic or congenital disorders of pituitary development. It could be isolated or combined with other types of hypopituitarism. This study aims to evaluate the prevalence of combined hypopituitarism and its associated factors in patients with CGHD.Patients and Methods: We conducted a retrospective study (1991-2019) at the Endocrinology department of Hedi Chaker University Hos...

Introduction: Turner syndrome (TS) is a feminine chromosomic disease, defined as the partial or total loss of the X chromosome. Classic phenotype includes growth and pubertal retardation as well as a characteristic dysmorphic syndrome. Other accompanying comorbidities are frequently associated with TS such as metabolic diseases: overweight, diabetes, hypertension (HTA) and dyslipidemia. Through this report we aim to determine the frequency of metabolic diseases associated with...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. PCOS has two phenotypes, obese and lean, the latter being a much less common presentation of the syndrome.Aim: Compare PCOS outcomes in patients with obese PCOS and patients with lean PCOS.Methods: A retrospective, single-center, descriptive and comparative study including patients with PCOS followed at the endocrinology d...

Introduction: Turner syndrome (TS) is a genetic disease, attributable to the total or partial loss of an X chromosome. The classic phenotype encompasses short stature, hypergonadotropic hypogonadism and dysmorphic features. It’s also associated with other conditions such as autoimmune (AI) diseases. Aim: Herein we aim to determine the frequency of AI diseases in TS and to identify the genetic variants of TS mostly associated with this latter conditi...